منابع مشابه
Scaffold proteins in mammalian MAP kinase cascades.
The mitogen-activated protein kinase (MAPK) signaling pathway, which is conserved from yeast to humans, is activated in response to a variety of extra- and intracellular stimuli, and plays key roles in multiple cellular processes, including proliferation, differentiation, and apoptosis. The MAPK pathway transmits its signal through the sequential phosphorylation of MAPK kinase kinase to MAPK ki...
متن کاملGuanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules.
Membrane-associated guanylate kinases (MAGUKs) are a large family of scaffold proteins that play essential roles in tissue developments, cell-cell communications, cell polarity control, and cellular signal transductions. Despite extensive studies over the past two decades, the functions of the signature guanylate kinase domain (GK) of MAGUKs are poorly understood. Here we show that the GK domai...
متن کاملMAP Kinase Modules: Many Roads Home
MAP kinases are a family of enzymes that coordinate diverse cellular programs in response to signals relayed from the extracellular milieu. They are components of signalling pathways that have a common architecture, in which the MAP kinases themselves are the terminal members of a three-component linear kinase cascade. The MAP kinases are activated by dual phosphorylation on a conserved Thr-Xxx...
متن کاملMembrane Localization of Scaffold Proteins Promotes Graded Signaling in the Yeast MAP Kinase Cascade
BACKGROUND Signaling through mitogen-activated protein kinase (MAPK) cascade pathways can show various input-output behaviors, including either switch-like or graded responses to increasing levels of stimulus. Prior studies suggest that switch-like behavior is promoted by positive feedback loops and nonprocessive phosphorylation reactions, but it is unclear whether graded signaling is a default...
متن کاملMolecular Glue: Kinase Anchoring and Scaffold Proteins
This pathway proceeds from the membrane bound gua-nine nucleotide-binding protein Ras, through the se-Vollum Institute, Oregon Health Sciences University quential activation of the cytoplasmic serine/threonine Mail Code L474 kinases Raf, MAP-kinase kinase (MEK), and MAP kinase Portland Oregon, 97201–3098 (MAPK) and leads to specific gene expression in the nucleus. In the budding yeast S. cerevi...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2007
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1210411